Drug interactions
Same + Trimipramine
Severity: Moderate
Same and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has serotonergic activity, and with a tricyclic antidepressant there are reports of additive serotonergic effects including rare serotonin syndrome. Evidence is mostly limited reports.
What this interaction means in plain words
Same and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity; SAMe may increase monoamine turnover while trimipramine modulates reuptake.
What to do
Avoid starting SAMe without prescriber review and use low doses if combined. Monitor for agitation, tremor, sweating, and hyperreflexia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Same with Trimipramine?
MediHelp rates the interaction as moderate. Same and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) has serotonergic activity, and with a tricyclic antidepressant there are reports of additive serotonergic effects including rare serotonin syndrome. Evidence is mostly limited reports.
How serious is the interaction between Same and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting SAMe without prescriber review and use low doses if combined. Monitor for agitation, tremor, sweating, and hyperreflexia.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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