Drug interactions
Sarecycline + Saxagliptin-metformin
Severity: Minor
Sarecycline and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-glycoprotein inhibitor in vitro, so it could modestly raise saxagliptin concentrations. Saxagliptin is only a modest P-gp substrate and a clinically meaningful effect is unlikely.
What this interaction means in plain words
Sarecycline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sarecycline belongs to Anti Bacterial; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Possible P-glycoprotein inhibition by sarecycline may slightly reduce saxagliptin efflux.
What to do
No dose adjustment is needed; be aware of possible increased saxagliptin adverse effects if the patient presents with them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Sarecycline with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Sarecycline and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-glycoprotein inhibitor in vitro, so it could modestly raise saxagliptin concentrations. Saxagliptin is only a modest P-gp substrate and a clinically meaningful effect is unlikely.
How serious is the interaction between Sarecycline and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of possible increased saxagliptin adverse effects if the patient presents with them.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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