Drug interactions
Sarecycline + Sitagliptin
Severity: Minor
Sarecycline and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-glycoprotein and could slightly raise sitagliptin concentrations. A clinically meaningful effect is unlikely given sitagliptin's wide therapeutic margin.
What this interaction means in plain words
Sarecycline and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sarecycline belongs to Anti Bacterial; Sitagliptin belongs to Endocrine.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing sitagliptin efflux.
What to do
No dose change is normally needed. Monitor for sitagliptin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sarecycline and Sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Sarecycline with Sitagliptin?
MediHelp rates the interaction as minor. Sarecycline and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-glycoprotein and could slightly raise sitagliptin concentrations. A clinically meaningful effect is unlikely given sitagliptin's wide therapeutic margin.
How serious is the interaction between Sarecycline and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor for sitagliptin adverse effects.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
