Drug interactions
Sarecycline + Verapamil
Severity: Minor
Sarecycline and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-glycoprotein and raise concentrations of P-gp substrates such as verapamil. The clinical effect is likely small, but verapamil effects such as bradycardia and hypotension could be enhanced.
What this interaction means in plain words
Sarecycline and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sarecycline belongs to Anti Bacterial; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by sarecycline may increase verapamil absorption.
What to do
Monitor heart rate and blood pressure when sarecycline is started; reduce the verapamil dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Sarecycline with Verapamil?
MediHelp rates the interaction as minor. Sarecycline and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-glycoprotein and raise concentrations of P-gp substrates such as verapamil. The clinical effect is likely small, but verapamil effects such as bradycardia and hypotension could be enhanced.
How serious is the interaction between Sarecycline and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when sarecycline is started; reduce the verapamil dose if bradycardia or hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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