Drug interactions
Saxagliptin + Somatrogon
Severity: Moderate
Saxagliptin and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon is a growth hormone analog that can decrease insulin sensitivity and increase blood glucose. This may reduce the effectiveness of saxagliptin in patients with diabetes.
What this interaction means in plain words
Saxagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and opposes the glucose-lowering action of antidiabetic agents.
What to do
Monitor glucose and HbA1c when somatrogon is started or the dose is changed. Adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Saxagliptin with Somatrogon?
MediHelp rates the interaction as moderate. Saxagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon is a growth hormone analog that can decrease insulin sensitivity and increase blood glucose. This may reduce the effectiveness of saxagliptin in patients with diabetes.
How serious is the interaction between Saxagliptin and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when somatrogon is started or the dose is changed. Adjust the antidiabetic therapy as needed.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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