Drug interactions
Saxagliptin + Sotorasib
Severity: Minor
Saxagliptin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor and can raise exposure to P-gp substrates, but it also induces CYP3A4 weakly to moderately. The net effect on saxagliptin is uncertain and probably small.
What this interaction means in plain words
Saxagliptin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Sotorasib alters P-gp transport and CYP3A4 activity, so the net effect on saxagliptin exposure is not well established.
What to do
No empirical dose change is needed. Monitor glycemic control when sotorasib is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Saxagliptin with Sotorasib?
MediHelp rates the interaction as minor. Saxagliptin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-gp inhibitor and can raise exposure to P-gp substrates, but it also induces CYP3A4 weakly to moderately. The net effect on saxagliptin is uncertain and probably small.
How serious is the interaction between Saxagliptin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor glycemic control when sotorasib is started or stopped.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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