Drug interactions
Saxagliptin-metformin + Tafenoquine
Severity: Moderate
Saxagliptin-metformin and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits the renal transporters OCT2 and MATE, which clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in renal impairment.
What this interaction means in plain words
Saxagliptin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE transporters, reducing renal tubular secretion of metformin.
What to do
Monitor for metformin toxicity and glycemic control, and consider reducing the metformin dose. Avoid in patients with impaired renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Saxagliptin-metformin with Tafenoquine?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits the renal transporters OCT2 and MATE, which clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in renal impairment.
How serious is the interaction between Saxagliptin-metformin and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin toxicity and glycemic control, and consider reducing the metformin dose. Avoid in patients with impaired renal function.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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