Drug interactions
Saxagliptin-metformin + Thioridazine
Severity: Moderate
Saxagliptin-metformin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines like thioridazine may worsen glucose tolerance and reduce antidiabetic efficacy. Glucose control may improve again if thioridazine is withdrawn.
What this interaction means in plain words
Saxagliptin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through reduced insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose when thioridazine is started, changed or stopped. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Thioridazine?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines like thioridazine may worsen glucose tolerance and reduce antidiabetic efficacy. Glucose control may improve again if thioridazine is withdrawn.
How serious is the interaction between Saxagliptin-metformin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when thioridazine is started, changed or stopped. Adjust antidiabetic doses as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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