Drug interactions
Saxagliptin-metformin + Tranylcypromine
Severity: Moderate
Saxagliptin-metformin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as tranylcypromine can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The risk is modest with these agents but may be additive.
What this interaction means in plain words
Saxagliptin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Non-selective MAO inhibition may enhance insulin sensitivity and hypoglycemic effects.
What to do
Monitor blood glucose when starting, changing or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Tranylcypromine?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as tranylcypromine can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The risk is modest with these agents but may be additive.
How serious is the interaction between Saxagliptin-metformin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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