Drug interactions
Saxagliptin-metformin + Verapamil
Severity: Minor
Saxagliptin-metformin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may inhibit hepatic uptake of metformin and has been shown to reduce its glucose-lowering effect in some studies. Verapamil is also a moderate CYP3A4 inhibitor, which may modestly increase saxagliptin exposure.
What this interaction means in plain words
Saxagliptin-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of OCT1-mediated hepatic uptake of metformin, plus moderate CYP3A4 inhibition affecting saxagliptin.
What to do
Monitor glycemic control when verapamil is started or stopped. Adjust the antidiabetic regimen if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Saxagliptin-metformin with Verapamil?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may inhibit hepatic uptake of metformin and has been shown to reduce its glucose-lowering effect in some studies. Verapamil is also a moderate CYP3A4 inhibitor, which may modestly increase saxagliptin exposure.
How serious is the interaction between Saxagliptin-metformin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when verapamil is started or stopped. Adjust the antidiabetic regimen if control changes.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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