Drug interactions
Saxagliptin-metformin + Zafirlukast
Severity: Minor
Saxagliptin-metformin and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP3A4 to a limited extent and could slightly raise saxagliptin levels. A clinically important effect is not expected.
What this interaction means in plain words
Saxagliptin-metformin and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4 reduces saxagliptin metabolism.
What to do
No dose adjustment is needed; routine glucose monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Saxagliptin-metformin with Zafirlukast?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP3A4 to a limited extent and could slightly raise saxagliptin levels. A clinically important effect is not expected.
How serious is the interaction between Saxagliptin-metformin and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine glucose monitoring is sufficient.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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