Drug interactions
Saxagliptin-metformin + Ziprasidone
Severity: Minor
Saxagliptin-metformin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as ziprasidone can disturb glucose regulation, although ziprasidone has relatively low metabolic liability. In patients treated with saxagliptin and metformin, glycemic control may deteriorate and require adjustments.
What this interaction means in plain words
Saxagliptin-metformin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin-metformin belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition: antipsychotic-related changes in insulin sensitivity may counteract the antihyperglycemic effect of the antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c after starting or changing ziprasidone. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Ziprasidone?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics such as ziprasidone can disturb glucose regulation, although ziprasidone has relatively low metabolic liability. In patients treated with saxagliptin and metformin, glycemic control may deteriorate and require adjustments.
How serious is the interaction between Saxagliptin-metformin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing ziprasidone. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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