Drug interactions
Scopolamine + Succinylcholine
Severity: Minor
Scopolamine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine is a depolarizing neuromuscular blocker that can cause bradycardia through muscarinic stimulation, particularly with repeat doses. Antimuscarinics such as scopolamine are used to prevent this, so the interaction is mostly beneficial and no meaningful interference with neuromuscular blockade is expected.
What this interaction means in plain words
Scopolamine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Scopolamine belongs to Respiratory; Succinylcholine belongs to Musculoskeletal.
Why it happens
Muscarinic blockade by scopolamine counteracts the muscarinic effects of succinylcholine.
What to do
No routine change is needed; monitor heart rate and rhythm during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Scopolamine and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Scopolamine
Other interactions of Succinylcholine
Frequently asked questions
Can I take Scopolamine with Succinylcholine?
MediHelp rates the interaction as minor. Scopolamine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine is a depolarizing neuromuscular blocker that can cause bradycardia through muscarinic stimulation, particularly with repeat doses. Antimuscarinics such as scopolamine are used to prevent this, so the interaction is mostly beneficial and no meaningful interference with neuromuscular blockade is expected.
How serious is the interaction between Scopolamine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor heart rate and rhythm during anesthesia.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
