Drug interactions
Scullcap + Trimipramine
Severity: Minor
Scullcap and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap has reputed sedative properties that may add to the marked sedation of trimipramine. This can impair alertness and psychomotor performance.
What this interaction means in plain words
Scullcap and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects, probably via GABAergic activity; not well characterized.
What to do
Advise patients to avoid driving or operating machinery until the combined effect is known. Consider stopping the herbal product if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Scullcap with Trimipramine?
MediHelp rates the interaction as minor. Scullcap and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Scullcap has reputed sedative properties that may add to the marked sedation of trimipramine. This can impair alertness and psychomotor performance.
How serious is the interaction between Scullcap and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or operating machinery until the combined effect is known. Consider stopping the herbal product if excessive drowsiness occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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