Drug interactions
Secobarbital + Selexipag
Severity: Moderate
Secobarbital and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower exposure to selexipag and its active metabolite via enzyme induction, which could reduce efficacy in pulmonary arterial hypertension. The labeled concern is with strong CYP2C8 inducers, and barbiturate data are limited.
What this interaction means in plain words
Secobarbital and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Selexipag belongs to Cardiovascular.
Why it happens
Hepatic enzyme induction increases metabolism of selexipag and its active metabolite.
What to do
Monitor clinical response in pulmonary arterial hypertension and adjust the selexipag dose upward if needed. Reduce the dose again after stopping the barbiturate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Secobarbital with Selexipag?
MediHelp rates the interaction as moderate. Secobarbital and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower exposure to selexipag and its active metabolite via enzyme induction, which could reduce efficacy in pulmonary arterial hypertension. The labeled concern is with strong CYP2C8 inducers, and barbiturate data are limited.
How serious is the interaction between Secobarbital and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response in pulmonary arterial hypertension and adjust the selexipag dose upward if needed. Reduce the dose again after stopping the barbiturate.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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