Drug interactions
Secobarbital + Thioridazine
Severity: Moderate
Secobarbital and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so together they can cause marked sedation, hypotension and impaired psychomotor function. Barbiturate enzyme induction may also alter thioridazine levels.
What this interaction means in plain words
Secobarbital and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible barbiturate-induced changes in thioridazine metabolism.
What to do
Monitor sedation level and blood pressure, and adjust doses to the lowest effective amounts. Keep ECG monitoring in place per thioridazine precautions if dosing changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Secobarbital with Thioridazine?
MediHelp rates the interaction as moderate. Secobarbital and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so together they can cause marked sedation, hypotension and impaired psychomotor function. Barbiturate enzyme induction may also alter thioridazine levels.
How serious is the interaction between Secobarbital and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and blood pressure, and adjust doses to the lowest effective amounts. Keep ECG monitoring in place per thioridazine precautions if dosing changes.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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