Drug interactions
Secobarbital + Tolbutamide
Severity: Minor
Secobarbital and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can induce tolbutamide metabolism, which could reduce its glucose-lowering effect. Clinical significance is likely small, but glucose control could worsen.
What this interaction means in plain words
Secobarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Secobarbital belongs to Central Nervous System; Tolbutamide belongs to Endocrine.
Why it happens
Barbiturate induction of CYP2C9 increases tolbutamide clearance.
What to do
Monitor blood glucose when secobarbital is started or stopped and adjust the tolbutamide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Secobarbital with Tolbutamide?
MediHelp rates the interaction as minor. Secobarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates can induce tolbutamide metabolism, which could reduce its glucose-lowering effect. Clinical significance is likely small, but glucose control could worsen.
How serious is the interaction between Secobarbital and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when secobarbital is started or stopped and adjust the tolbutamide dose if needed.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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