Drug interactions
Secobarbital + Tranylcypromine
Severity: Moderate
Secobarbital and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may prolong and intensify barbiturate effects, causing excessive sedation. The interaction is largely theoretical.
What this interaction means in plain words
Secobarbital and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition may reduce barbiturate metabolism and add to CNS depression.
What to do
Use a reduced secobarbital dose and monitor for oversedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Secobarbital with Tranylcypromine?
MediHelp rates the interaction as moderate. Secobarbital and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may prolong and intensify barbiturate effects, causing excessive sedation. The interaction is largely theoretical.
How serious is the interaction between Secobarbital and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced secobarbital dose and monitor for oversedation and hypotension.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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