Drug interactions
Secobarbital + Vinblastine
Severity: Moderate
Secobarbital and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a CYP3A4 substrate, so barbiturate induction could reduce its exposure and efficacy.
What this interaction means in plain words
Secobarbital and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Vinblastine belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases vinblastine clearance.
What to do
Prefer a non-inducing sedative and monitor tumor response and toxicity if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Secobarbital with Vinblastine?
MediHelp rates the interaction as moderate. Secobarbital and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinblastine is a CYP3A4 substrate, so barbiturate induction could reduce its exposure and efficacy.
How serious is the interaction between Secobarbital and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative and monitor tumor response and toxicity if the combination is used.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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