Drug interactions
Selegiline + Tapentadol
Severity: Contraindicated
Selegiline and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tapentadol is contraindicated with MAO inhibitors, including selegiline, because of the risk of serotonin syndrome and hypertensive reactions.
What this interaction means in plain words
Selegiline and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Selegiline belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with tapentadol's noradrenaline reuptake inhibition.
What to do
Do not use within 14 days of selegiline. Use an alternative non-serotonergic analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Tapentadol?
MediHelp rates the interaction as contraindicated. Selegiline and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tapentadol is contraindicated with MAO inhibitors, including selegiline, because of the risk of serotonin syndrome and hypertensive reactions.
How serious is the interaction between Selegiline and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 14 days of selegiline. Use an alternative non-serotonergic analgesic.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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