Drug interactions
Selegiline + Zolmitriptan
Severity: Moderate
Selegiline and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolmitriptan and its active metabolite are cleared partly by MAO-A, so MAO inhibition may raise exposure. Combined with serotonergic effects, this raises the risk of serotonin syndrome.
What this interaction means in plain words
Selegiline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Reduced MAO-A metabolism of zolmitriptan and additive serotonergic activity.
What to do
Keep zolmitriptan at the lowest effective dose and monitor for serotonin toxicity. Avoid the combination with nonselective-dose or transdermal selegiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Selegiline with Zolmitriptan?
MediHelp rates the interaction as moderate. Selegiline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zolmitriptan and its active metabolite are cleared partly by MAO-A, so MAO inhibition may raise exposure. Combined with serotonergic effects, this raises the risk of serotonin syndrome.
How serious is the interaction between Selegiline and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep zolmitriptan at the lowest effective dose and monitor for serotonin toxicity. Avoid the combination with nonselective-dose or transdermal selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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