Drug interactions
Selegiline transdermal + Sevoflurane
Severity: Moderate
Selegiline transdermal and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline inhibits monoamine oxidase and may alter hemodynamic responses during anesthesia. Hypotension or blood pressure instability can occur with sevoflurane, and sympathomimetic or opioid drugs given during the procedure carry added risk.
What this interaction means in plain words
Selegiline transdermal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition combined with anesthetic cardiovascular depression; the interaction is predicted and not well characterized.
What to do
Inform the anesthesia team of the MAO inhibitor and monitor blood pressure and heart rate closely. Avoid meperidine, indirect-acting sympathomimetics and other serotonergic drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Selegiline transdermal with Sevoflurane?
MediHelp rates the interaction as moderate. Selegiline transdermal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal selegiline inhibits monoamine oxidase and may alter hemodynamic responses during anesthesia. Hypotension or blood pressure instability can occur with sevoflurane, and sympathomimetic or opioid drugs given during the procedure carry added risk.
How serious is the interaction between Selegiline transdermal and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of the MAO inhibitor and monitor blood pressure and heart rate closely. Avoid meperidine, indirect-acting sympathomimetics and other serotonergic drugs.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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