Drug interactions
Selegiline transdermal + Trimipramine
Severity: Contraindicated
Selegiline transdermal and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a tricyclic antidepressant with an MAO inhibitor such as transdermal selegiline can cause serotonin syndrome and hypertensive reactions. Selegiline labeling advises against use with tricyclic antidepressants, and the risk persists after stopping either agent.
What this interaction means in plain words
Selegiline transdermal and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of MAO combined with TCA-mediated inhibition of serotonin and norepinephrine reuptake produces excess monoaminergic activity.
What to do
Do not coadminister. Allow a washout of at least 2 weeks after stopping selegiline before starting trimipramine, and an appropriate washout after stopping trimipramine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Selegiline transdermal with Trimipramine?
MediHelp rates the interaction as contraindicated. Selegiline transdermal and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with an MAO inhibitor such as transdermal selegiline can cause serotonin syndrome and hypertensive reactions. Selegiline labeling advises against use with tricyclic antidepressants, and the risk persists after stopping either agent.
How serious is the interaction between Selegiline transdermal and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow a washout of at least 2 weeks after stopping selegiline before starting trimipramine, and an appropriate washout after stopping trimipramine before starting selegiline.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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