Drug interactions
Selegiline + Vortioxetine
Severity: Contraindicated
Selegiline and Vortioxetine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline with vortioxetine may cause serotonin syndrome, with hyperthermia, rigidity, myoclonus and mental status changes. Vortioxetine labeling contraindicates MAO inhibitors, including selegiline.
What this interaction means in plain words
Selegiline and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Selegiline belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with serotonin transporter blockade increases synaptic serotonin.
What to do
Do not use together. Allow at least 14 days after stopping selegiline before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Selegiline with Vortioxetine?
MediHelp rates the interaction as contraindicated. Selegiline and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline with vortioxetine may cause serotonin syndrome, with hyperthermia, rigidity, myoclonus and mental status changes. Vortioxetine labeling contraindicates MAO inhibitors, including selegiline.
How serious is the interaction between Selegiline and Vortioxetine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days after stopping selegiline before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting selegiline.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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