Drug interactions
Selinexor + Sunitinib
Severity: Moderate
Selinexor and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes fatigue, dizziness, confusion and nausea. Sunitinib also causes fatigue and gastrointestinal toxicity, so overlapping adverse effects may worsen tolerability, but no defined pharmacokinetic interaction exists.
What this interaction means in plain words
Selinexor and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Overlapping adverse effects; no specific mechanism established.
What to do
Monitor for fatigue, dizziness, cytopenias and gastrointestinal effects. Use antiemetic prophylaxis and adjust doses if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Sunitinib?
MediHelp rates the interaction as moderate. Selinexor and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes fatigue, dizziness, confusion and nausea. Sunitinib also causes fatigue and gastrointestinal toxicity, so overlapping adverse effects may worsen tolerability, but no defined pharmacokinetic interaction exists.
How serious is the interaction between Selinexor and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fatigue, dizziness, cytopenias and gastrointestinal effects. Use antiemetic prophylaxis and adjust doses if toxicity occurs.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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