Drug interactions
Selinexor + Vincristine
Severity: Moderate
Selinexor and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neurological adverse effects, with selinexor causing dizziness, confusion, and fatigue and vincristine causing peripheral and autonomic neuropathy. Combined use may add to neurological burden, though there is no established pharmacokinetic interaction.
What this interaction means in plain words
Selinexor and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Additive neurotoxicity; no specific pharmacokinetic mechanism is established.
What to do
Monitor for neuropathy, dizziness, confusion, and falls, and reduce or hold doses of either drug if neurotoxicity becomes significant. Counsel patients about fall risk and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Vincristine?
MediHelp rates the interaction as moderate. Selinexor and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neurological adverse effects, with selinexor causing dizziness, confusion, and fatigue and vincristine causing peripheral and autonomic neuropathy. Combined use may add to neurological burden, though there is no established pharmacokinetic interaction.
How serious is the interaction between Selinexor and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, dizziness, confusion, and falls, and reduce or hold doses of either drug if neurotoxicity becomes significant. Counsel patients about fall risk and driving.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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