Drug interactions
Selinexor + Vinorelbine
Severity: Moderate
Selinexor and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neurologic effects, with selinexor causing dizziness, confusion and fatigue and vinorelbine causing peripheral and autonomic neuropathy. Both also cause nausea and cytopenias, so toxicity may overlap. No specific pharmacokinetic interaction is established.
What this interaction means in plain words
Selinexor and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicities; no specific mechanism is established.
What to do
Monitor for neurologic symptoms, falls, GI toxicity and blood counts, and provide antiemetic prophylaxis. Reduce or hold either drug if toxicity becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Vinorelbine?
MediHelp rates the interaction as moderate. Selinexor and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neurologic effects, with selinexor causing dizziness, confusion and fatigue and vinorelbine causing peripheral and autonomic neuropathy. Both also cause nausea and cytopenias, so toxicity may overlap. No specific pharmacokinetic interaction is established.
How serious is the interaction between Selinexor and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic symptoms, falls, GI toxicity and blood counts, and provide antiemetic prophylaxis. Reduce or hold either drug if toxicity becomes significant.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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