Drug interactions
Selpercatinib + Solifenacin
Severity: Major
Selpercatinib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval and solifenacin has dose-related QT effects, so the combination may increase arrhythmia risk. Selpercatinib is also a weak CYP3A4 inhibitor which may modestly increase solifenacin levels.
What this interaction means in plain words
Selpercatinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Selpercatinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation with possible mild CYP3A4 inhibition.
What to do
Monitor ECG and electrolytes at baseline and during treatment. Avoid the combination in patients with QT risk factors and consider a non-QT-prolonging bladder agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Selpercatinib and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Solifenacin
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Solifenacin?
MediHelp rates the interaction as major. Selpercatinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can prolong the QT interval and solifenacin has dose-related QT effects, so the combination may increase arrhythmia risk. Selpercatinib is also a weak CYP3A4 inhibitor which may modestly increase solifenacin levels.
How serious is the interaction between Selpercatinib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during treatment. Avoid the combination in patients with QT risk factors and consider a non-QT-prolonging bladder agent.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
