Drug interactions
Selpercatinib + Tacrolimus
Severity: Moderate
Selpercatinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Selpercatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selpercatinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Tacrolimus?
MediHelp rates the interaction as moderate. Selpercatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Selpercatinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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