Drug interactions
Semaglutide + Tolazamide
Severity: Moderate
Semaglutide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide combined with a sulfonylurea increases the risk of hypoglycemia, since both promote insulin secretion. Risk is greatest at initiation and during dose escalation.
What this interaction means in plain words
Semaglutide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Semaglutide belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive stimulation of insulin secretion by sulfonylurea and GLP-1 receptor agonism.
What to do
Consider reducing the tolazamide dose when starting semaglutide and monitor blood glucose during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Semaglutide
Frequently asked questions
Can I take Semaglutide with Tolazamide?
MediHelp rates the interaction as moderate. Semaglutide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide combined with a sulfonylurea increases the risk of hypoglycemia, since both promote insulin secretion. Risk is greatest at initiation and during dose escalation.
How serious is the interaction between Semaglutide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when starting semaglutide and monitor blood glucose during titration.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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