Drug interactions
Semaglutide + Tolbutamide
Severity: Moderate
Semaglutide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide enhances glucose-dependent insulin secretion, and with a sulfonylurea the risk of hypoglycemia increases.
What this interaction means in plain words
Semaglutide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Semaglutide belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive insulin secretagogue effects: GLP-1 receptor agonism plus sulfonylurea-induced insulin release.
What to do
Consider lowering the tolbutamide dose when semaglutide is started and monitor blood glucose. Counsel the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Semaglutide
Frequently asked questions
Can I take Semaglutide with Tolbutamide?
MediHelp rates the interaction as moderate. Semaglutide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide enhances glucose-dependent insulin secretion, and with a sulfonylurea the risk of hypoglycemia increases.
How serious is the interaction between Semaglutide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the tolbutamide dose when semaglutide is started and monitor blood glucose. Counsel the patient on hypoglycemia.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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