Drug interactions
Sertraline + Sparsentan
Severity: Moderate
Sertraline and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 substrate and a CYP2C19 inducer, while sertraline is a weak CYP3A4 inhibitor and CYP2C19 substrate. Sparsentan may reduce sertraline exposure and its antidepressant effect, and the reverse effect on sparsentan is likely small.
What this interaction means in plain words
Sertraline and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2C19, increasing sertraline clearance, and sertraline weakly inhibits CYP3A4.
What to do
Monitor for reduced antidepressant response and adjust sertraline dose if needed. Continue routine blood pressure, potassium and renal monitoring for sparsentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sertraline with Sparsentan?
MediHelp rates the interaction as moderate. Sertraline and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan is a CYP3A4 substrate and a CYP2C19 inducer, while sertraline is a weak CYP3A4 inhibitor and CYP2C19 substrate. Sparsentan may reduce sertraline exposure and its antidepressant effect, and the reverse effect on sparsentan is likely small.
How serious is the interaction between Sertraline and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and adjust sertraline dose if needed. Continue routine blood pressure, potassium and renal monitoring for sparsentan.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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