Drug interactions
Sertraline + Sufentanil
Severity: Moderate
Sertraline and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity, including fentanyl-class agents such as sufentanil, have been associated with serotonin syndrome when given with SSRIs. Sedation and respiratory depression may also be additive.
What this interaction means in plain words
Sertraline and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive serotonergic effect and additive CNS depression.
What to do
Monitor for signs of serotonin syndrome and respiratory depression, particularly after starting or raising doses. Use the lowest effective sufentanil dose and consider alternative analgesia if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sertraline with Sufentanil?
MediHelp rates the interaction as moderate. Sertraline and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity, including fentanyl-class agents such as sufentanil, have been associated with serotonin syndrome when given with SSRIs. Sedation and respiratory depression may also be additive.
How serious is the interaction between Sertraline and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and respiratory depression, particularly after starting or raising doses. Use the lowest effective sufentanil dose and consider alternative analgesia if symptoms appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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