Drug interactions
Sertraline + Sulindac
Severity: Moderate
Sertraline and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline reduces platelet serotonin and aggregation, and sulindac adds mucosal injury and platelet inhibition. The combination increases the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Sertraline and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
Additive effects: SSRI-induced platelet serotonin depletion plus NSAID cyclooxygenase inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Limit the NSAID duration or use paracetamol instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Sulindac?
MediHelp rates the interaction as moderate. Sertraline and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline reduces platelet serotonin and aggregation, and sulindac adds mucosal injury and platelet inhibition. The combination increases the risk of upper gastrointestinal bleeding.
How serious is the interaction between Sertraline and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Limit the NSAID duration or use paracetamol instead.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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