Drug interactions
Sertraline + Tolfenamic acid
Severity: Moderate
Sertraline and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID increases the risk of gastrointestinal bleeding beyond that of either drug alone. The risk is greatest in older patients and those with prior ulcers or on anticoagulants.
What this interaction means in plain words
Sertraline and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation while NSAIDs inhibit platelet cyclooxygenase and damage gastric mucosa, producing additive bleeding risk.
What to do
Avoid the combination if possible or use the lowest NSAID dose for the shortest time. Consider adding a proton pump inhibitor in at-risk patients and monitor for GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Sertraline with Tolfenamic acid?
MediHelp rates the interaction as moderate. Sertraline and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID increases the risk of gastrointestinal bleeding beyond that of either drug alone. The risk is greatest in older patients and those with prior ulcers or on anticoagulants.
How serious is the interaction between Sertraline and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or use the lowest NSAID dose for the shortest time. Consider adding a proton pump inhibitor in at-risk patients and monitor for GI bleeding signs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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