Drug interactions
Sertraline + Tranylcypromine
Severity: Contraindicated
Sertraline and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining sertraline with tranylcypromine can cause severe, potentially fatal serotonin syndrome and hypertensive reactions. Onset may be rapid and include hyperthermia, rigidity, seizures and coma.
What this interaction means in plain words
Sertraline and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sertraline belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition together with irreversible MAO inhibition causes excess serotonergic activity.
What to do
Do not coadminister. Observe at least 14 days after stopping tranylcypromine before starting sertraline, and at least 14 days after stopping sertraline before starting tranylcypromine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Sertraline with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Sertraline and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining sertraline with tranylcypromine can cause severe, potentially fatal serotonin syndrome and hypertensive reactions. Onset may be rapid and include hyperthermia, rigidity, seizures and coma.
How serious is the interaction between Sertraline and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Observe at least 14 days after stopping tranylcypromine before starting sertraline, and at least 14 days after stopping sertraline before starting tranylcypromine.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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