Drug interactions
Sertraline + Venetoclax
Severity: Minor
Sertraline and Venetoclax: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax is metabolized by CYP3A, and sertraline is a weak CYP3A inhibitor at most. A clinically significant increase in venetoclax exposure is not expected, unlike with moderate or strong CYP3A inhibitors.
What this interaction means in plain words
Sertraline and Venetoclax have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Venetoclax belongs to Miscellaneous.
Why it happens
Weak CYP3A inhibition by sertraline may marginally raise venetoclax concentrations.
What to do
No venetoclax dose reduction is needed. Monitor blood counts and for tumor lysis syndrome as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Sertraline with Venetoclax?
MediHelp rates the interaction as minor. Sertraline and Venetoclax have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venetoclax is metabolized by CYP3A, and sertraline is a weak CYP3A inhibitor at most. A clinically significant increase in venetoclax exposure is not expected, unlike with moderate or strong CYP3A inhibitors.
How serious is the interaction between Sertraline and Venetoclax?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No venetoclax dose reduction is needed. Monitor blood counts and for tumor lysis syndrome as routine.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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