Drug interactions
Sertraline + Voclosporin
Severity: Moderate
Sertraline and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak CYP3A4 inhibitor and may modestly raise voclosporin levels, which could increase nephrotoxicity and other calcineurin inhibitor toxicity. Both drugs can also affect QT interval.
What this interaction means in plain words
Sertraline and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by sertraline reduces voclosporin metabolism, together with additive QT effects.
What to do
Monitor eGFR, blood pressure and potassium when starting or stopping sertraline, and adjust the voclosporin dose per labeling if toxicity occurs. Consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sertraline and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Sertraline with Voclosporin?
MediHelp rates the interaction as moderate. Sertraline and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline is a weak CYP3A4 inhibitor and may modestly raise voclosporin levels, which could increase nephrotoxicity and other calcineurin inhibitor toxicity. Both drugs can also affect QT interval.
How serious is the interaction between Sertraline and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, blood pressure and potassium when starting or stopping sertraline, and adjust the voclosporin dose per labeling if toxicity occurs. Consider an ECG in patients with other QT risk factors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
