Drug interactions
Sertraline + Ziprasidone
Severity: Moderate
Sertraline and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone clearly prolongs the QT interval, and sertraline has a low potential for QT effect, so the combined risk is mainly driven by ziprasidone. Caution is still needed because of additive risk in susceptible patients.
What this interaction means in plain words
Sertraline and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible small additive QT prolongation; sertraline has minimal CYP effect on ziprasidone.
What to do
Obtain a baseline ECG and electrolytes before combining, and repeat if risk factors are present. Stop ziprasidone or reassess therapy if QTc exceeds about 500 ms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Sertraline with Ziprasidone?
MediHelp rates the interaction as moderate. Sertraline and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone clearly prolongs the QT interval, and sertraline has a low potential for QT effect, so the combined risk is mainly driven by ziprasidone. Caution is still needed because of additive risk in susceptible patients.
How serious is the interaction between Sertraline and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes before combining, and repeat if risk factors are present. Stop ziprasidone or reassess therapy if QTc exceeds about 500 ms.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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