Drug interactions
Sevelamer + Vadadustat
Severity: Moderate
Sevelamer and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevelamer can bind vadadustat in the gut and reduce its absorption, which may lessen its effect on anemia.
What this interaction means in plain words
Sevelamer and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevelamer belongs to Miscellaneous; Vadadustat belongs to Endocrine.
Why it happens
Binding of vadadustat in the gastrointestinal tract, reducing absorption.
What to do
Give vadadustat at least 1 hour before or 2 hours after sevelamer. Monitor hemoglobin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevelamer
- Carbamazepine + Sevelamer Moderate
- Ciprofloxacin + Sevelamer Moderate
- Dichlorphenamide + Sevelamer Moderate
- Erdafitinib + Sevelamer Moderate
- Gabapentin + Sevelamer Moderate
- Mycophenolic acid + Sevelamer Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Sevelamer with Vadadustat?
MediHelp rates the interaction as moderate. Sevelamer and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevelamer can bind vadadustat in the gut and reduce its absorption, which may lessen its effect on anemia.
How serious is the interaction between Sevelamer and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vadadustat at least 1 hour before or 2 hours after sevelamer. Monitor hemoglobin response.
What other medicines interact with Sevelamer?
MediHelp also lists interactions of Sevelamer with, for example, Carbamazepine, Ciprofloxacin, Dichlorphenamide. The full list is on the Sevelamer page.
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