Drug interactions
Sevoflurane + Sufentanil sl
Severity: Major
Sevoflurane and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with volatile anesthetics produce additive sedation, hypotension and respiratory depression. With sublingual sufentanil, profound sedation, coma and death are possible if the two are combined without adjustment.
What this interaction means in plain words
Sevoflurane and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and volatile anesthetic action, with additive vasodilation and hypotension.
What to do
Reduce anesthetic and opioid doses and titrate to effect, with continuous monitoring of respiratory rate, oxygen saturation and blood pressure. Ensure airway management capability and extended postoperative observation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Sufentanil sl?
MediHelp rates the interaction as major. Sevoflurane and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with volatile anesthetics produce additive sedation, hypotension and respiratory depression. With sublingual sufentanil, profound sedation, coma and death are possible if the two are combined without adjustment.
How serious is the interaction between Sevoflurane and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce anesthetic and opioid doses and titrate to effect, with continuous monitoring of respiratory rate, oxygen saturation and blood pressure. Ensure airway management capability and extended postoperative observation.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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