Drug interactions
Sevoflurane + Thiothixene
Severity: Moderate
Sevoflurane and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic that can add to the depressant effects of sevoflurane. Patients may show deeper sedation, hypotension and slower emergence.
What this interaction means in plain words
Sevoflurane and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-adrenergic blockade from the antipsychotic combined with anesthetic-induced vasodilation.
What to do
Reduce sevoflurane dosing as guided by depth-of-anesthesia monitoring and watch blood pressure closely. Be ready to support circulation and ventilation in the recovery period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Thiothixene?
MediHelp rates the interaction as moderate. Sevoflurane and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic that can add to the depressant effects of sevoflurane. Patients may show deeper sedation, hypotension and slower emergence.
How serious is the interaction between Sevoflurane and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce sevoflurane dosing as guided by depth-of-anesthesia monitoring and watch blood pressure closely. Be ready to support circulation and ventilation in the recovery period.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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