Drug interactions
Sevoflurane + Triazolam
Severity: Moderate
Sevoflurane and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam, a potent short-acting benzodiazepine, adds to the CNS depressant effect of sevoflurane. This may result in deeper sedation, prolonged recovery, hypotension and respiratory depression.
What this interaction means in plain words
Sevoflurane and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A receptor potentiation by both agents.
What to do
Titrate sevoflurane to clinical effect with anesthetic depth monitoring, anticipating a reduced requirement. Monitor respiratory rate, oxygen saturation and blood pressure until fully recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Triazolam?
MediHelp rates the interaction as moderate. Sevoflurane and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam, a potent short-acting benzodiazepine, adds to the CNS depressant effect of sevoflurane. This may result in deeper sedation, prolonged recovery, hypotension and respiratory depression.
How serious is the interaction between Sevoflurane and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to clinical effect with anesthetic depth monitoring, anticipating a reduced requirement. Monitor respiratory rate, oxygen saturation and blood pressure until fully recovered.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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