Drug interactions
Sevoflurane + Triclofos
Severity: Moderate
Sevoflurane and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol and can add to the sedative effect of sevoflurane. Excess sedation, respiratory depression and delayed awakening may occur.
What this interaction means in plain words
Sevoflurane and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the active metabolite trichloroethanol and the volatile anesthetic, both enhancing GABA-A activity.
What to do
Lower the sevoflurane dose as guided by depth-of-anesthesia monitoring and observe respiratory function until the patient is fully awake. Avoid additional sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Triclofos?
MediHelp rates the interaction as moderate. Sevoflurane and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol and can add to the sedative effect of sevoflurane. Excess sedation, respiratory depression and delayed awakening may occur.
How serious is the interaction between Sevoflurane and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the sevoflurane dose as guided by depth-of-anesthesia monitoring and observe respiratory function until the patient is fully awake. Avoid additional sedatives where possible.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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