Drug interactions
Sevoflurane + Venlafaxine
Severity: Moderate
Sevoflurane and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and venlafaxine has a small QT effect, so together the arrhythmia risk may rise during anaesthesia in susceptible patients.
What this interaction means in plain words
Sevoflurane and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarisation.
What to do
Continue venlafaxine perioperatively to avoid withdrawal, with a baseline ECG and normal electrolytes. Monitor the ECG during anaesthesia in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Venlafaxine?
MediHelp rates the interaction as moderate. Sevoflurane and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and venlafaxine has a small QT effect, so together the arrhythmia risk may rise during anaesthesia in susceptible patients.
How serious is the interaction between Sevoflurane and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue venlafaxine perioperatively to avoid withdrawal, with a baseline ECG and normal electrolytes. Monitor the ECG during anaesthesia in high-risk patients.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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