Drug interactions
Sildenafil + Sotalol
Severity: Minor
Sildenafil and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil's vasodilatory effect can add to sotalol's blood pressure lowering, occasionally causing dizziness or hypotension. The interaction is usually modest.
What this interaction means in plain words
Sildenafil and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sildenafil belongs to Genitourinary; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotension from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure and warn about orthostatic symptoms when initiating sildenafil. Start with a low dose in patients with marginal blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sildenafil with Sotalol?
MediHelp rates the interaction as minor. Sildenafil and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sildenafil's vasodilatory effect can add to sotalol's blood pressure lowering, occasionally causing dizziness or hypotension. The interaction is usually modest.
How serious is the interaction between Sildenafil and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and warn about orthostatic symptoms when initiating sildenafil. Start with a low dose in patients with marginal blood pressure.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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