Drug interactions
Sildenafil + Stiripentol
Severity: Moderate
Sildenafil and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so sildenafil exposure may be raised or lowered unpredictably. This may cause either adverse effects or loss of efficacy.
What this interaction means in plain words
Sildenafil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sildenafil belongs to Genitourinary; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters sildenafil metabolism.
What to do
Monitor sildenafil response and tolerability, and adjust the dose according to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Sildenafil with Stiripentol?
MediHelp rates the interaction as moderate. Sildenafil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so sildenafil exposure may be raised or lowered unpredictably. This may cause either adverse effects or loss of efficacy.
How serious is the interaction between Sildenafil and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sildenafil response and tolerability, and adjust the dose according to clinical effect.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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