Drug interactions
Simvastatin + Voclosporin
Severity: Moderate
Simvastatin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may raise simvastatin concentrations, increasing the risk of myopathy.
What this interaction means in plain words
Simvastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Simvastatin belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Voclosporin inhibits OATP1B1, reducing hepatic uptake of simvastatin and its acid.
What to do
Use the lowest effective simvastatin dose and monitor for muscle symptoms. Consider a statin less affected by OATP1B1, such as fluvastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Simvastatin with Voclosporin?
MediHelp rates the interaction as moderate. Simvastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin may raise simvastatin concentrations, increasing the risk of myopathy.
How serious is the interaction between Simvastatin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective simvastatin dose and monitor for muscle symptoms. Consider a statin less affected by OATP1B1, such as fluvastatin.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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