Drug interactions
Sirolimus + Somapacitan
Severity: Minor
Sirolimus and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity and could lower sirolimus levels. The effect is likely modest, but sirolimus has a narrow therapeutic range.
What this interaction means in plain words
Sirolimus and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone may induce CYP3A4-mediated metabolism, increasing sirolimus clearance.
What to do
Check sirolimus trough levels after starting or adjusting somapacitan in transplant patients. Increase the sirolimus dose only if levels fall below target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Sirolimus with Somapacitan?
MediHelp rates the interaction as minor. Sirolimus and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450 activity and could lower sirolimus levels. The effect is likely modest, but sirolimus has a narrow therapeutic range.
How serious is the interaction between Sirolimus and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough levels after starting or adjusting somapacitan in transplant patients. Increase the sirolimus dose only if levels fall below target.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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