Drug interactions
Sirolimus + Tisagenlecleucel
Severity: Moderate
Sirolimus and Tisagenlecleucel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressants such as sirolimus may impair expansion and persistence of CAR-T cells, potentially reducing efficacy. They also add to infection risk after lymphodepletion.
What this interaction means in plain words
Sirolimus and Tisagenlecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Why it happens
Immunosuppression inhibits T-cell proliferation, including that of CAR-T cells.
What to do
Avoid sirolimus around the time of infusion unless clinically necessary. Monitor for infection and CAR-T response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Sirolimus with Tisagenlecleucel?
MediHelp rates the interaction as moderate. Sirolimus and Tisagenlecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressants such as sirolimus may impair expansion and persistence of CAR-T cells, potentially reducing efficacy. They also add to infection risk after lymphodepletion.
How serious is the interaction between Sirolimus and Tisagenlecleucel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sirolimus around the time of infusion unless clinically necessary. Monitor for infection and CAR-T response.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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